Manufacturer GENWAY
Type Antibody
Specific against Mouse
Applications WB, IF
Amount 0.1 mg
Host Rat
ArtNr 20-783-314642
Genway ID:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Mouse TREM-1 Fc fusion protein
Recognises mouse triggering receptor expressed on myeloid cells 1 (TREM-1) a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock By similarity. Subunit structureInteracts with TYROBP/DAP12 By similarity. Monomer. Ref. 3Subcellular locationMembrane; Single-pass type I membrane protein By similarity. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. \" Walczak H. Degli-Esposti M. A. Johnson R. S. Smolak P. J. Waugh J. Y. Boiani N. Timour M. S. Gerhart M. J. Schooley K. A. Smith C. A. Goodwin R. G. Rauch C. T. EMBO J. 16:5386-5397(1997) [PubMed: 9311998] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG) PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Foreskin fibroblast. [2] \" TRICK2 a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. \" Screaton G. R. Mongkolsapaya J. Xu X. -N. Cowper A. E. McMichael A. J. Bell J. I. Curr. Biol. 7:693-696(1997) [PubMed: 9285725] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT) ALTERNATIVE SPLICING VARIANTS LEU-32 AND VAL-67. [3] \" Characterization of two receptors for TRAIL. \" Schneider P. Bodmer J. -L. Thome M. Hofmann K. Holler N. Tschopp J. FEBS Lett. 416:329-334(1997) [PubMed: 9373179] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG) CHARACTERIZATION VARIANTS LEU-32 AND VAL-67. Tissue: Liver and Spleen. [4] \" KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. \" Wu G. S. Burns T. F. McDonald E. R. III Jiang W. Meng R. Krantz I. D. Kao G. Gan D. D. Zhou J. Y. Muschel R. Hamilton S. R. Spinner N. B. Markowitz S. Wu G. el-Deiry W. S. Nat. Genet. 17:141-143(1997) [PubMed: 9326928] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Ovary. [5] \" An antagonist decoy receptor and a death domain-containing receptor for TRAIL. \" Pan G. Ni J. Wei Y. -F. Yu G. -L. Gentz R. Dixit V. M. Science 277:815-818(1997) [PubMed: 9242610] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). [6] \" Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. \" MacFarlane M. Ahmad M. Srinivasula S. M. Fernandes-Alnemri T. Cohen G. M. Alnemri E. S. J. Biol. Chem. 272:25417-25420(1997) [PubMed: 9325248] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT) VARIANTS LEU-32 AND VAL-67. [7] \" Death receptor 5 a new member of the TNFR family and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. \" Chaudhary P. M. Eby M. Jasmin A. Bookwalter A. Murray J. Hood L. Immunity 7:821-830(1997) [PubMed: 9430227] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT) VARIANTS LEU-32 AND VAL-67. [8] \" Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. \" Sheridan J. P. Marsters S. A. Pitti R. M. Gurney A. Skubatch M. Baldwin D. T. Ramakrishnan L. Gray C. L. Baker K. Wood W. I. Goddard A. D. Godowski P. J. Ashkenazi A. Science 277:818-821(1997) [PubMed: 9242611] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT) VARIANT LEU-32. [9] \" Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. \" Arai T. Akiyama Y. Okabe S. Saito K. Iwai T. Yuasa Y. Cancer Lett. 133:197-204(1998) [PubMed: 10072170] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] ALTERNATIVE SPLICING VARIANTS LEU-32 AND VAL-67. [10] Cao X. Zhang W. Wan T. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Amount: 0.1 mg
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