RAT ANTI MOUSE CD98

GWB-A09006

IgG1

Phosphate buffered saline pH7. 4

Thymic epithelial cells from mouse

Required for the function of light chain amino-acid transporters. Involved in sodium-independent high-affinity transport of large neutral amino acids such as phenylalanine tyrosine leucine arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger following an antiport mechanism for amino acid transport influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1 is also involved in the transport of L-DOPA across the blood-brain barrier and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D L-homocysteine complexes and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8 involved in the cellular activity of small molecular weight nitrosothiols via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1 regulates the transport activity LAT2 in polarized intestinal cells by generating and delivering intracellular signals. When associated with SLC7A5 plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Ref. 6Ref. 7Ref. 9Subunit structureDisulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5 SLC7A6 SLCA7A7 SLC7A8 SLC7A10 or SLCA7A11). Colocalizes with cadherins By similarity. Interacts with FAM57A/CT120 and ICAM1 By similarity. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1 alpha-3/beta-1 alpha-5/beta-1 and alpha-6/beta-1) but minimally with alpha-4/beta-1 By similarity. Ref. 6Ref. 7Ref. 8Subcellular locationApical cell membrane; Single-pass type II membrane protein. Melanosome By similarity.

Leucine uptake was inhibited by ileum valine histidine and phenylalanine as well as by 2-aminobicyclo-(2 2 1)-heptane-2-carboxylic acid (BCH) (a specific inhibitor of system L transport). Sequence similaritiesBelongs to the SLC3A transporter family. [1] \" A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. \" Mizushima N. Sugita H. Yoshimori T. Ohsumi Y. J. Biol. Chem. 273:33889-33892(1998) [PubMed: 9852036] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) CONJUGATION TO ATG5 TISSUE SPECIFICITY. [2] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Ovary.