RAT ANTI MOUSE ABCA1:FITC

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314751
Available
Genway ID:
GWB-C53C10
Specificity:
ABCA1
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Immunogen:
Syhthetic peptide corresponding to aa 215-233
Specificity:
Recognises murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease. Mutations in ABCA1 gene have been associated with Tangiers disease a genetic disorder of lipid metabolism and familial high density lipoprotein (HDL) deficiency. Recommended Negative Controls: RAT IgG1 NEGATIVE CONTROL:FITC
Function:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport By similarity. Subunit structureInteracts with MEGF10. Ref. 5Subcellular locationMembrane; Multi-pass membrane protein Potential. Tissue specificityWidely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.
Induction:
Down-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). Ref. 3Ref. 4
Domain:
Multifunctional polypeptide with two homologous halves each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Post-translational modificationPhosphorylation on Ser-2054 regulates phospholipid efflux By similarity. Palmitoylation by DHHC8 is essential for membrane localization By similarity. Sequence similaritiesBelongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. Sequence cautionThe sequence AAG39073. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA53530. 1 differs from that shown. Reason: Erroneous initiation.
Amount: 0.1 mg
Available: In stock
Listprice: €283.64
Discount: -10.0%
Price: €255.28
You save: €28.36
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