RAT ANTI MOUSE CD49d

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Applications IP
Amount 0.02 mg
Host Rat
ArtNr 20-783-314921
Available
Genway ID:
GWB-623CF6
Specificity:
CD49d
Isotype:
IgG2bSpecies Cross Reactivity: Reacts with: HumanN. B. Antibody reactivity and working conditions may vary between species.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1. 0 mg/ml
Specificity:
Recognises murine alpha 4 integrin (CD49d) a 150kD glycoprotein that can associate with either beta 1 integrin (CD29) or beta 7 integrin to form heterodimers CD49d/CD29 (VLA-4) and alpha4/beta7 (LPAM-1) respectively. CD49d is expressed on most lymphocytes granulocytes monocytes and thymocytes. The primary ligands for CD49d are CD106 (VCAM-1) fibronectin and MAdCAM-1. Clone PS/2 has also been reported to block the binding of CD49d to its ligands (3). Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:
Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. Mice homozygous for a null mutation of the alpha-4 subunit gene die by day E11-E14 from detachment and rupture of the epicardium and coronary arteries. Subunit structureHeterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityPeyer patch homing cells.
Domain:
The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion By similarity. Post-translational modificationPhosphorylation on Ser-1028 inhibits PXN binding By similarity. Sequence similaritiesBelongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. 1. Weiss D. et al. (2008) Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. J. Leukoc. Biol. 83: 48-55.
Amount: 0.02 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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