RAT ANTI MOUSE CD19

GWB-948CDB

IgG2a

Phosphate buffered saline pH7. 4

Human K562 cell line transfected with murine CD19

Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Subunit structureForms a complex with CD21 CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402 By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Post-translational modificationPhosphorylated upon DNA damage probably by ATM or ATR By similarity. Ref. 5Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Arase H. et al. (2001) Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin very late antigen-2) J. Immunol. 167: 1141 - 1144. [1] \" The mouse VLA-2 homologue supports collagen and laminin adhesion but not virus binding. \" Edelman J. M. Chan B. M. Uniyal S. Onodera H. Wang D. Z. Damjanovich L. Latzer D. B. Finberg R. W. Bergelson J. M. Cell Adhes. Commun. 2:131-143(1994) [PubMed: 8081889] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Lung. [2] \" Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. \" Wu J. E. Santoro S. A. Dev. Dyn. 199:292-314(1994) [PubMed: 7521231] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 450-1178. Tissue: Lung. [3] \" Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. \" Pellinen T. Arjonen A. Vuoriluoto K. Kallio K. Fransen J. A. M. Ivaska J. J. Cell Biol. 173:767-780(2006) [PubMed: 16754960] [Abstract]Cited for: INTERACTION WITH RAB21.