RAT ANTI MOUSE CD34:RPE

CD34

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityHighly expressed in hematopoietic progenitor cell lines brain and testis and moderately in the thymus spleen and bone marrow but not in adult liver. Post-translational modificationHighly glycosylated By similarity. Ref. 5Phosphorylated on serine residues by PKC By similarity. Ref. 4Sequence similaritiesBelongs to the CD34 family. [1] \" Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. \" Rosendahl M. S. Ko S. C. Long D. L. Brewer M. T. Rosenzweig B. Hedl E. Anderson L. Pyle S. M. Moreland J. Meyers M. A. Kohno T. Lyons D. Lichenstein H. S. J. Biol. Chem. 272:24588-24593(1997) [PubMed: 9305925] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PROTEIN SEQUENCE OF 216-237. [2] \" Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. \" Howard L. Mitchell S. Lu X. Griffiths S. Glynn P. Biochem. J. 317:45-50(1996) [PubMed: 8694785] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-748. [3] \" Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. \" McKie N. Edwards T. Dallas D. J. Houghton A. Stringer B. Graham R. Russell G. Croucher P. I. Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed: 9016778] [Abstract]Cited for: TISSUE SPECIFICITY. [4] \" ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. \" Gutwein P. Mechtersheimer S. Riedle S. Stoeck A. Gast D. Joumaa S. Zentgraf H. Fogel M. Altevogt P. FASEB J. 17:292-294(2003) [PubMed: 12475894] [Abstract]Cited for: FUNCTION. [5] \" The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. \" Vincent B. Paitel E. Saftig P. Frobert Y. Hartmann D. De Strooper B. Grassi J. Lopez-Perez E. Checler F. J. Biol. Chem. 276:37743-37746(2001) [PubMed: 11477090] [Abstract]Cited for: FUNCTION. [6] \" ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. \" Chubinskaya S. Mikhail R. Deutsch A. Tindal M. H. J. Histochem. Cytochem. 49:1165-1176(2001) [PubMed: 11511685] [Abstract]Cited for: TISSUE SPECIFICITY. [7] \" Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. \" Lemjabbar H. Basbaum C. Nat. Med. 8:41-46(2002) [PubMed: 11786905] [Abstract]Cited for: FUNCTION. [8] \" Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. \" Lewandrowski U. Moebius J. Walter U. Sickmann A. Mol. Cell. Proteomics 5:226-233(2006) [PubMed: 16263699] [Abstract]Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-278 MASS SPECTROMETRY. Tissue: Platelet. [9] \" Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. \" Chen R. Jiang X. Sun D. Han G. Wang F. Ye M. Wang L. Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-278 MASS SPECTROMETRY. Tissue: Liver. [10] \" Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. \" Wollscheid B. Bausch-Fluck D. Henderson C. O\' Brien R. Bibel M. Schiess R. Aebersold R. Watts J. D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract]Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-278 MASS SPECTROMETRY. Tissue: Leukemic T-cell.