RAT ANTI MOUSE CD107b:RPE

CD107b

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises murine CD107b also known as MAC-3 and LAMP-2. CD107b is a transmembrane glycoprotein that is associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b does vary between cell populations and the molecular weight of CD107b can vary between 92-120kD. Studies suggest that CD107b may be involved in leucocyte adhesion.

This protein shuttles between lysosomes endosomes and the plasma membrane. Post-translational modificationO- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans By similarity. Sequence similaritiesBelongs to the LAMP family. 1. O\' Connell M. J. and Cimprich K. A (2005) G2 damage checkpoints: what is the turn-on? J. Cell Sci. 118: 1-6. [1] \" Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. \" Sanchez Y. Wong C. Thoma R. S. Richman R. Wu Z. Piwnica-Worms H. Elledge S. J. Science 277:1497-1501(1997) [PubMed: 9278511] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION INTERACTION WITH CDC25A; CDC25B AND CDC25C SUBCELLULAR LOCATION TISSUE SPECIFICITY PHOSPHORYLATION MUTAGENESIS OF ASP-130. [2] \" Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. \" Flaggs G. Plug A. W. Dunks K. M. Mundt K. E. Ford J. C. Quiggle M. R. E. Taylor E. M. Westphal C. H. Ashley T. Hoekstra M. F. Carr A. M. Curr. Biol. 7:977-986(1997) [PubMed: 9382850] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum stomach and endometrium. \" Semba S. Ouyang H. Han S. -Y. Kato Y. Horii A. Int. J. Oncol. 16:731-737(2000) [PubMed: 10717241] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [4] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. [5] NIEHS SNPs programSubmitted (JUL-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT GLN-156. [6] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow and Muscle. [8] \" The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. \" Shieh S. -Y. Ahn J. Tamai K. Taya Y. Prives C. Genes Dev. 14:289-300(2000) [PubMed: 10673501] [Abstract]Cited for: FUNCTION MUTAGENESIS OF ASP-130. [9] ErratumShieh S. -Y. Ahn J. Tamai K. Taya Y. Prives C. Genes Dev. 14:750-750(2000) [10] \" Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. \" Liu Q. Guntuku S. Cui X. -S. Matsuoka S. Cortez D. Tamai K. Luo G. Carattini-Rivera S. DeMayo F. Bradley A. Donehower L. A. Elledge S. J. Genes Dev. 14:1448-1459(2000) [PubMed: 10859164] [Abstract]Cited for: PHOSPHORYLATION AT SER-345.