RAT ANTI MOUSE ABCA1:RPE

GWB-5AA06D

IgG2a

Phosphate buffered saline pH7. 4

ABCA1 transfected HeLa cells.

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport By similarity. Subunit structureInteracts with MEGF10. Ref. 5Subcellular locationMembrane; Multi-pass membrane protein Potential. Tissue specificityWidely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.

Multifunctional polypeptide with two homologous halves each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Post-translational modificationPhosphorylation on Ser-2054 regulates phospholipid efflux By similarity. Palmitoylation by DHHC8 is essential for membrane localization By similarity. Sequence similaritiesBelongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. Sequence cautionThe sequence AAG39073. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA53530. 1 differs from that shown. Reason: Erroneous initiation. [1] \" Isolation and characterization of human defensin cDNA clones. \" Daher K. A. Lehrer R. I. Ganz T. Kronenberg M. Proc. Natl. Acad. Sci. U. S. A. 85:7327-7331(1988) [PubMed: 3174637] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" A myeloid-related sequence that localizes to human chromosome 8q21. 1-22. \" Mars W. M. vanTuinen P. Drabkin H. A. White J. W. Saunders G. F. Blood 71:1713-1719(1988) [PubMed: 3370315] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Differentiation stage-specific expression of a gene during granulopoiesis. \" Wiedemann L. M. Francis G. E. Lamb R. F. Burns J. H. Winnie J. N. McKenzie E. D. Birnie G. D. Leukemia 3:227-234(1989) [PubMed: 2918759] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3. \" Mars W. M. Patmasiriwat P. Maity T. Huff V. Weil M. M. Saunders G. F. J. Biol. Chem. 270:30371-30376(1995) [PubMed: 8530462] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" The structure of neutrophil defensin genes. \" Linzmeier R. Michaelson D. Liu L. Ganz T. FEBS Lett. 321:267-273(1993) [PubMed: 8477861] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] ErratumLinzmeier R. Michaelson D. Liu L. Ganz T. FEBS Lett. 326:299-300(1993) [PubMed: 8325384] [Abstract] [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [8] \" Primary structures of three human neutrophil defensins. \" Selsted M. E. Harwig S. S. L. Ganz T. Schilling J. W. Lehrer R. I. J. Clin. Invest. 76:1436-1439(1985) [PubMed: 4056036] [Abstract]Cited for: PROTEIN SEQUENCE OF 65-94. [9] \" Signal peptide prediction based on analysis of experimentally verified cleavage sites. \" Zhang Z. Henzel W. J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]Cited for: PROTEIN SEQUENCE OF 20-34. [10] \" Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide. \" Selsted M. E. Harwig S. S. L. J. Biol. Chem. 264:4003-4007(1989) [PubMed: 2917986] [Abstract]Cited for: DISULFIDE BONDS.