Rat Anti-Mouse CD11a (LFA-1)

GWB-FB3102

I21/7

subunit (Mr 180 kDa) of LFA-1The monoclonal antibody I21/7 reacts with the subunit of mouse CD11a also known as Leukocyte Function-associated Antigen-1 (LFA-1) and a member of the integrin family of cell adhesion molecules. 1 2 The antigen is expressed on thymocytes T and B lymphocytes and on non-lymphoid cells in the bone marrow. 2 CD11a appears to be an essential component for T-cell activation by antigen-presenting cells and is important for cell-mediated killing. Co-stimulatory signaling by LFA-1 is achieved by pairing with its ligand CD54/ICAM-1. 1 2

Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

Leukocytes.

Belongs to the integrin alpha chain family.

Contains 1 VWFA domain. 1. Altin J. G. E. B. Pagler and C. R. Parrish. 1994. Eur. J. Immunol. 24:450. 2. Springer T. A. D. Davignon M. Ho K. Kurzinger E. Martz and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171. . 3. Makino M. K. Yoshimatsu M. Azuma Y. Okada Y. Hitoshi H. Yagita K. Takatsu and K. Komuro. 1995. J. Immunol. 155:974. . 4. Connolly M. K. E. A. Kitchens B. Chan P. Jardieu and D. Wofsy. 1994. Clin. Immunol. Immunopath. 72:198. . 5. SouthernBiotech. Unpublished observations.