Rat Anti-Mouse CD45 (LCA)

GWB-7584EF

I3/2. 3

Mouse CD45 (T200 or leukocyte common antigen/LCA all isoforms) CD45 is the common leukocyte antigen and is expressed on all cells of hematopoietic origin except erythrocytes. 1-4 CD45 exists as a number of different isoforms which result from alternative RNA splicing of exons 4 5 and 6. The I3/2. 3 monoclonal antibody recognizes a framework epitope present on all CD45 isoforms. 1-4 The CD45 molecule has been implicated as playing a key role in thymic development and in antigen-driven proliferation of T cells. 4

Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing. 1. Johnson P L. Greenbaum K. Bottomley and I. S. Trowbridge. 1989. J. Exp. Med. 169:1179. 2. Haidl I. D. D. H. W. Ng S. Rothenberger P. Johnson and W. A. Jefferies. 1996. Eur. J. Immunol. 25:3370. 3. Trowbridge I. S. 1978. J. Exp. Med. 148:313. 4. Trowbridge I. S and M. L. Thomas. 1994. Ann. Rev. Immunol. . 12:85