Rat Anti-Mouse CD45RC

GWB-801E2A

GL24

An exon C-dependent epitope of CD45 glycoprotein CD45RC represents an exon C-dependent isoform of CD45 glycoprotein. It is expressed at high density on all B lymphocytes at intermediate density on most CD8+ splenic T cells and on two subpopulations of CD4+ splenic T cells with high and low density of expression. CD45RC is also present on a small subset of thymocytes. 1-4.

Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits an dephosphorylates SKAP1 and FYN.

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.

The first PTPase domain interacts with SKAP1.

Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Contains 2 tyrosine-protein phosphatase domains. 1. Hathcock K. S. Laslo G. Dickler H. B. . Sharrow S. O. . Johnson P. Trowbridge I. S. and Hodes R. J. 1992. Immuol. 148:19. 2. Bottomly K. M. Luqman L. Greenbaum S. Carding J. West T. Pasqualini and D. B. Murphy. 1989. Eur. J. Immunol. 19:617. 3. Johnson P. L. Greenbaum K. Bottomly et al. 1989. J. Exp. Med. 169:1179. 4. Birkeland M. L. et al. 1988. J. Mol. Cell. Immunol. 4:71.