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ISGF3G (interferon-stimulated transcription factor 3. gamma 48kDa)

ISGF3G (interferon-stimulated transcription factor 3. gamma 48kDa)

Item no.	18-003-42030
Manufacturer	GENWAY
Amount	0.05 mg
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Hematology Leukemia Lymphoma Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody
Applications	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-8508EB
Similar products	18-003-42030
Available
Genway ID:	GWB-8508EB
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ISGF3G.
ELISA Titre:	1:312500
Category:	Helix-Turn-Helix
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. ISGF3G functions to recruit RNA polymerase II to the promoter of interferon-stimulated genes and requires histone deacetylases. Defects in ISGF3 can cause resistance to IFN-. (2a) treatment.
Function:	Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors Jak kinases (TYK2 and JAK1) are activated leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes which drive the cell in an antiviral state.
Subunit:	Interacts with STAT2 in the cytoplasm. Forms a complex with heterodimer STAT1/STAT2.
Subcellular Location:	Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Induction:	By IFN-alpha and IFN-beta.
Similarity:	Belongs to the IRF family.
Similarity:	Contains 1 tryptophan pentad repeat DNA-binding domain. Lau. J. F. . et al. . (2003) Mol. Cell. Biol. 23 (2). 620-628.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 11/27/2025

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