CEBPB (CCAAT/enhancer binding protein (C/EBP). beta)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CEBPB.

Transcription Factor Antibodies

Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction inflammation and hemopoiesis. The consensus recognition site is 5\' -T[TG]NNGNAA[TG]-3\' .

Nucleus.

Sumoylated by polymeric chains of SUMO2 or SUMO3.

Contains 1 bZIP domain. Summary: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha CEBP-delta and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene as well as to regulatory regions of several acute-phase and cytokine genes. In addition the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. Chen. C. . et al. . (2004) J. Biol. Chem. 279 (27). 27948-27956.