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HCLS1 (hematopoietic cell-specific Lyn substrate 1)

HCLS1 (hematopoietic cell-specific Lyn substrate 1)

Item no.	18-003-42253
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Western Blot Primary Antibodies By Organ Colorectal Cancer
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2582F7
Similar products	18-003-42253
Available
Genway ID:	GWB-2582F7
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human HCLS1.
ELISA Titre:	1:2500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. HS1 which is hematopoietic lineage cell-specific protein 1. is a substrate of protein tyrosine kinases in lymphocytes. it binds to F-actin. and promotes Arp2/3 complex-mediated actin polymerization. However. the mechanism for the interaction between HS1 a
Function:	Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Subunit:	Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1 through binding to its C-terminal region. Interacts with HS1BP3.
Subcellular Location:	Membrane; Peripheral membrane protein (Probable). Cytoplasm (Probable). Mitochondrion (Probable).
Tissue Specificity:	Expressed only in tissues and cells of hematopoietic origin. Developmental Stage: Expressed in early stage of myeloid and erythroid differentiation.
Ptm:	Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.
Similarity:	Contains 4 cortactin repeats.
Similarity:	Contains 1 SH3 domain. Ruzzene. M. . et al. . (2002) Biochem. J. 364 (Pt 1). 41-47.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/30/2025

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