ALF (TFIIA-alpha/beta-like factor)

GWB-A76816

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involves the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. ALF is a germ cell-specific counterpart of

Nucleus.

Belongs to the TFIIA subunit 1 family. Summary: The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This protein is a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants encoding distinct isoforms have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF) which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Upadhyaya. A. B. . et al. . (2002) J. Biol. Chem. 277 (37). 34208-34216.