CCNL1 (cyclin L1)

Item no.	18-003-42341
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Western Blot Proliferation Primary Antibodies By Organ Lung Cancer Bladder Cancer
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4AC1D8
Similar products	18-003-42341
Available
Genway ID:	GWB-4AC1D8
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CCNL1.
ELISA Titre:	1:62500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CCNL1 plays a critical role in the loco-regional progression of HNSCC and may serve as an indicator for occult advanced tumour stages. CCNL1 also plays a role in pre-mRNA splicing. has been shown to associate with the PITSLRE kinase. and is involved in pr
Function:	Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
Subunit:	Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDC2L1 or CDC2L2 and SFRS2.
Subcellular Location:	Nucleus speckle (By similarity). Note=More specifically found in nuclear intrachromatin granules clusters (IGC) also called nuclear speckles which are storage compartments for nuclear proteins involved in mRNA processing (By similarity).
Tissue Specificity:	Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
Domain:	Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
Miscellaneous:	CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.
Similarity:	Belongs to the cyclin family. Cyclin L subfamily. Clark. H. F. . et al. . (2003) Genome Res. 13 (10). 2265-2270.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/30/2025

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