CLDN1 (claudin 1)

GWB-28DEB3

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets. forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3 but not CLDN2 homopolymers. Directly interacts with TJP1/ZO-1 TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity). May interact with HCV E1 and E2 proteins.

Strongly expressed in liver and kidney. Expressed in heart brain spleen lung and testis.

Belongs to the claudin family. Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene a member of the claudin family is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. Coyne. C. B. . et al. . (2003) Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5). L1166-L1178.