CACNB1 (calcium channel. voltage-dependent. beta 1 subunit)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CACNB1.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. The protein encoded by CACNB1 belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition. increasing peak calcium current. controlling the alpha-1 subunit membrane targeting and

The L-type calcium channel is composed of four subunits: alpha-1 alpha-2 beta and gamma. Interacts with JSRP1 (By similarity).

Expressed in brain heart and spleen (isoform 1 and 3) and in skeletal muscle (isoform 2).

Contains 1 SH3 domain. Summary: The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition increasing peak calcium current controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. Hogan. K. . et al. . (1999) Neurosci. Lett. 277 (2). 111-114.