CCNH (cyclin H)

GWB-2F51AD

1:75000

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Cyclin H regulates CDK7. the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1. CDK2. CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcript

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Belongs to the cyclin family. Cyclin C subfamily. Summary: The protein encoded by this gene belongs to the highly conserved cyclin family whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes suggesting an important link between basal transcription control and the cell cycle machinery. Maekelae. T. P. . et al. . (1994) Nature 371:254-257.