KCNK5 (potassium channel. subfamily K. member 5)

GWB-DF57D7

1:62500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. KCNK5 is one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. KCNK5 is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH

Homodimer; disulfide-linked.

Abundant expression in kidney also detected in liver placenta and small intestine. In the kidney expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.

Belongs to the two pore domain potassium channel (TC 1. A. 1. 8) family [view classification]. Summary: This protein is one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this in combination with its expression pattern suggests it may play an important role in renal potassium transport. Rusznak. Z. . et al. . (2004) Cell. Mol. Life Sci. 61 (12). 1532-1542.