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CBX8 (chromobox homolog 8 (Pc class homolog. Drosophila))

CBX8 (chromobox homolog 8 (Pc class homolog. Drosophila))

Item no.	18-003-43274
Manufacturer	GENWAY
Amount	0.1 mg
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1FBF93
Similar products	18-003-43274
Available
Genway ID:	GWB-1FBF93
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CBX8.
ELISA Titre:	1:1562500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CBX8 is one of the proteins homolog to the Polycomb group (PcG) proteins. They assemble to form large multiprotein complexes involved in gene silencing. Evidence suggests that PcG complexes are heterogeneous with respect to both protein composition and sp
Function:	Component of the Polycomb group (PcG) multiprotein PRC1 complex a complex required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A \' Lys-119\' rendering chromatin heritably changed in its expressibility.
Subunit:	Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110 BMI1/PCGF4 CBX2/M33 CBX4/PC2 CBX8/PC3 PHC1 PHC2 PHC3 SCMH1 RING1 and RNF2/RING2. Interacts with MLLT3.
Subcellular Location:	Nucleus.
Similarity:	Contains 1 chromo domain. Bardos. J. I. . et al. . (2000) J. Biol. Chem. 275 (37). 28785-28792.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 7/24/2025

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