SMARCE1

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SMARCE1.

Transcription Factor Antibodies

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.

Nucleus.

Contains 1 HMG box DNA-binding domain. Summary: The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein either alone or when in the SWI/SNF complex can bind to 4-way junction DNA which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins this protein has no yeast counterpart. Chen. J. (2005) Mol. Cell. Biol. 25 (20). 9016-9027.