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ELL (elongation factor RNA polymerase II)

ELL (elongation factor RNA polymerase II)

Item no.	18-003-43492
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies By Cell Type Hematology Leukemia Lymphoma Sarcoma Myelofibrosis Immunohistochemistry Western Blot Primary Antibodies By Organ Testicular & Prostate Cancer
Type	Antibody
Applications	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B8FF02
Similar products	18-003-43492
Available
Genway ID:	GWB-B8FF02
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ELL.
ELISA Titre:	1:1562500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally. ELL resembles Elon
Function:	Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Subunit:	Interacts with EAF1 and EAF2.
Subcellular Location:	Nucleus speckle. Nucleus Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies.
Tissue Specificity:	Expressed in all tissues tested. Highest levels found in placenta skeletal muscle testis and peripheral blood leukocytes.
Ptm:	Phosphorylated upon DNA damage probably by ATM or ATR.
Disease:	A chromosomal translocation involving ELL is found in acute leukemias. Translocation t(11; 19)(q23; p13. 1) with MLL/HRX. The result is a rogue activator protein.
Similarity:	Belongs to the ELL/occludin family. Wiederschain. D. . (2003) Mol. Cell. Biol. 23 (12). 4230-4246.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/11/2025

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