STAT1

Item no.	18-003-43953
Manufacturer	GENWAY
Amount	0.1 mg
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1235D0
Similar products	18-003-43953
Available
Genway ID:	GWB-1235D0
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human Stat1.
ELISA Titre:	1:312500
Category:	TF for Mouse
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Stat1 is a member of the STAT family. It can form homodimers to modulate the transcriptional repression of PPARgamma2 in adipocytes.
Function:	Transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element. This multiprotein transcription factor is termed ISGF3.
Subunit:	In response to IFN alpha/beta three subunits (STAT1-alpha STAT1-beta STAT2) of ISGF3 become phosphorylated on tyrosine migrate into the nucleus and assemble into a complex together with ISGF3 gamma (p48) a DNA-binding protein that specifically binds to the IFN-stimulated response element. In response to IFN gamma STAT1 forms homodimers that also translocate into the nucleus to activate IFN gamma-responsive genes. Interacts with NMI (By similarity).
Subcellular Location:	Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Induction:	By IFN and EGF.
Ptm:	Tyrosine phosphorylated in response to IFN-gamma IFN-alpha PDGF and EGF. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Similarity:	Belongs to the transcription factor STAT family.
Similarity:	Contains 1 SH2 domain. Mikhak. Z. . et al. . (2006) J. Immunol. 176 (8). 4959-4967.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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