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AATF (apoptosis antagonizing transcription factor)

AATF (apoptosis antagonizing transcription factor)

Item no.	18-003-44099
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2E33DD
Similar products	18-003-44099
Available
Genway ID:	GWB-2E33DD
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human AATF.
ELISA Titre:	1:312500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. The AATF is a protein that was identified on the basis of its interaction with MAP3K12/DLK. a protein kinase known to be involved in the induction of cell apoptosis. AATF contains a leucine zipper. which is a characteristic motif of transcription factors.
Function:	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes leading to activation of E2F target genes and cell cycle progression. Conversely displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia) although the molecular basis for this phenomenon has not been described to date.
Subunit:	Binds PAWR POLR2J RB1/RB RBL1/P107 RBL2/P130 and SP1. May also bind MAPT.
Subcellular Location:	Nucleus nucleolus.
Tissue Specificity:	Ubiquitously expressed. Expressed at high levels in brain heart kidney placenta and thymus.
Ptm:	Hyperphosphorylated during the G1/S phase transition.
Similarity:	Belongs to the AATF family. Summary: The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK a protein kinase known to be involved in the induction of cell apoptosis. This protein product contains a leucine zipper which is a characteristic motif of transcription factors and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. Lehner. B. (2004) Genome Res. 14 (7). 1315-1323.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/11/2025

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