DNASE2B (deoxyribonuclease II beta)

GWB-2DB720

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. DNASE2B shares considerable sequence similarity to. and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitousSummary: The protein encoded by this gene shares considerable sequence similarity to and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22. 3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. MacLea. K. S. . (2003) Gene 305 (1). 1-12.