CDK9 (cyclin-dependent kinase 9 (CDC2-related kinase))

GWB-C87AA3

1:312500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CDK9 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28. and S. pombe cdc2. and known as important cell cycle regulators. This kinase was found to be a compone

ATP + a protein = ADP + a phosphoprotein.

Associates with CCNT1/cyclin-T1 to form P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Also associates with CCNK/cyclin-K. Component of a complex which is at least composed of HTATSF1/Tat-SF1 P-TEFb complex RNA pol II SUPT5H and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) HEXIM1 HEXIM2 BCDIN3 SART3 proteins and 7SK and U6 snRNAs.

Ubiquitous.

Contains 1 protein kinase domain. Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2 and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T which suggested a possible involvement of this protein in AIDS. Li. Q. . (2005) J. Biol. Chem. 280 (31). 28819-28826.