BRD4 (bromodomain containing 4)

GWB-D2E828

1:1562500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. BRD4 is homologous to the murine protein MCAP. which associates with chromosomes during mitosis. and to the human RING3 protein. a serine/threonine kinase. Each of these proteins contains two bromodomains. a conserved sequence motif which may be involvedSummary: The protein encoded by this gene is homologous to the murine protein MCAP which associates with chromosomes during mitosis and to the human RING3 protein a serine/threonine kinase. Each of these proteins contains two bromodomains a conserved sequence motif which may be involved in chromatin targeting. This protein has been implicated as the chromosome 19 target of translocation t(15; 19)(q13; p13. 1) which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. Schweiger. M. R. . (2006) J. Virol. 80 (9). 4276-4285.