LMX1A (LIM homeobox transcription factor 1. alpha)

GWB-76EF95

1:62500

Acts as a transcriptional activator by binding to an A/T-rich sequence the FLAT element in the insulin gene promoter. Required for development of the roof plate and in turn for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).

Isoform 1 is expressed in many tissues. Not found in heart liver spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis.

Contains 2 LIM zinc-binding domains. Summary: Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al. 1994 [PubMed 7698771]). [supplied by OMIM]. Millen. K. J. . (2004) Dev. Biol. 270 (2). 382-392.