SIRT3 (sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae))

GWB-26D649

1:62500

NAD-dependent deacetylase. Despite some ability to deacetylate histones in vitro it is unlikely in vivo.

Mitochondrion matrix.

Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.

Contains 1 deacetylase sirtuin-type domain. Summary: This protein is a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. Onyango. P. . et al. . (2002) Proc. Natl. Acad. Sci. U. S. A. 15 99(21). 13653-8.