Comparison

Snurportin1

Item no. 18-202-335571
Manufacturer GENWAY
Amount 0,1 mg
Type Antibody
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-10C3A2
Similar products 18-202-335571
Available
Genway ID:
GWB-10C3A2
Sequence:
Peptide with sequence SHSPDHPGCLMEN from the C Terminus of the protein sequence according to NP_005692. Notes: Peptide ELISA: antibody detection limit dilution 1:2 000. Western Blot: Preliminary experiments gave no signal but low background in Hela and Human Brain extracts at up to 1ug/ml. Summary: The nuclear import of the spliceosomal snRNPs U1 U2 U4 and U5 is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5\' -2 2 7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [1] Ospina J. K. Gonsalvez G. B. Bednenko J. Darzynkiewicz E. Gerace L. and Matera A. G. Cross-talk between snurportin1 subdomains[2] Stelzl U. Worm U. Lalowski M. Haenig C. Brembeck F. H. Goehler H. Stroedicke M. Zenkner M. Schoenherr A. Koeppen S. et al. A human protein-protein interaction network: a resource for annotating the proteome[3] Strasser A. Dickmanns A. Luhrmann R. and Ficner R. et al. Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1[4] Yong J. Wan L. and Dreyfuss G. et al. Why do cells need an assembly machine for RNA-protein complexes?[5] Narayanan U. Ospina J. K. Frey M. R. Hebert M. D. and Matera A. G. et al. SMN the spinal muscular atrophy protein forms a pre-import snRNP complex with snurportin1 and importin beta

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0,1 mg
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close