IPF1 / PDX1

GWB-25982C

Peptide with sequence C-AAEPEENKRTRTA from the internal region of Notes: Peptide ELISA: antibody detection limit dilution 1:1 000. Western Blot: Preliminary experiments in Human Pancreas lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Summary: The protein encoded by this gene is a transcriptional activator of several genes including insulin somatostatin glucokinase islet amyloid polypeptide and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM) as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq]. [1] Yoshida T. Kato K. Fujimaki T. Yokoi K. Oguri M. Watanabe S. Metoki N. Yoshida H. Satoh K. Aoyagi Y. Nishigaki Y. et al. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome[2] Anney R. J. Lasky-Su J. O\' Dushlaine C. Kenny E. Neale B. M. Mulligan A. Franke B. Zhou K. Chen W. Christiansen H. et al. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study[3] Gupta D. Jetton T. L. Mortensen R. M. Duan S. Z. Peshavaria M. and Leahy J. L. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter[4] Plengvidhya N. Boonyasrisawat W. Chongjaroen N. Jungtrakoon P. Sriussadaporn S. Vannaseang S. Banchuin N. and et al. Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus[5] Jonmarker S. Glaessgen A. Culp W. D. Pisa P. Lewensohn R. Ekman P. Valdman A. and Egevad L. Expression of PDX-1 in prostate cancer prostatic intraepithelial neoplasia and benign prostatic tissue