SHIP

A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.

WB: 1:500FC: 1:50. SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3 4 5-triphosphate to phosphatidylinositol-3 4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif immunoreceptor tyrosine-based inhibition motif (ITIM) present in the cytoplasmic domain of FcgammaRIIB1 (1). Also results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation respectively (2). 1. Jabbour L et al. Genomics 81(3):292-303 2003. 2. Liu YJ et al. Hum Mol Genet 17(12):1803-1813 2008. 3. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487