alpha 2 Catenin

IgG

Human

alpha 2 Catenin Storage

WB: Use at a dilution of 1/1000. Detects a band of approximately 102 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. The catenins (alpha beta and gamma) are cytoplasmic proteins found in varying abundance in many developing and adult tissues. Catenins bind directly or indirectly to the conserved cytoplasmic tail domain of the cell adhesion cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network. Catenins/cadherin complexes play an important role in mediating cell adhesion transduction of cell-cell contact positional signals to the cell interior and may play a crucial role in cell differentiation. Alpha-Catenin (CAP102 102 kDa) originally described as an E-cadherin associated protein has been shown to associate with other members of the cadherin family members N-cadherin and P-cadherin.

Binds MLLT4 and F-actin. Interacts directly with CTNNB1 and PSEN1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB (By similarity).

Sumoylated (By similarity).