gamma Catenin

GWB-77AF70

Synthetic peptide (Human) (C terminal).

Breast carcinoma

Cytoplasmic

Phosphate-buffered saline pH 7. 4 containing 1% BSA and 0. 09% sodium azide

82 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.

Cell junction adherens junction. Cell junction desmosome. Cytoplasm cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form.

Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle electrical instability and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings replacement of ventricular myocardium with fatty and fibrous elements preferentially involve the right ventricular free wall.

Contains 9 ARM repeats.