GPRC1A (ready-to-use)

IgG

Human

GPRC1A

PBS pH 7. 4 containing 1%BSA and 0. 1% sodium azide

Integral membrane protein L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology putative signal transduction mechanisms and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4 GRM6 GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1 HOMER2 and HOMER3. Interacts with SIAH1 RYR1 RYR2 ITPR1 SHANK1 SHANK3 and GRASP (By similarity).

Belongs to the G-protein coupled receptor 3 family [view classification].