Ubiquitin (ready-to-use)

GWB-7DAFA9

Full length native protein (purified) (Human).

Human brain from a patient with Alzheimer\' s disease

Cytoplasmic and Nuclear

PBS pH 7. 4 containing 1%BSA and 0. 1% sodium azide

Cytoplasmic and Nuclear Ubiquitin is a highly conserved protein of about 8. 5 kDa molecular weight which has a normal role in the targeting of proteins for proteolytic degradation. To perform this function the protein to be degraded is first covalently attached to the C terminus of ubiquitin and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly ubiquitin also becomes covalently bonded to many types of pathological inclusions which appear to be resistant to normal degradation. Therefore ubiquitin antibodies are very useful for studies of these inclusions. For example the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer\' s disease Lewy bodies seen in Parkinson\' s disease and Pick bodies found in Pick\' s disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.

Cytoplasm. Nucleus.

Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).