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Caspase 6

Caspase 6

Item no.	18-272-196811
Manufacturer	GENWAY
Amount	0.25 mg
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-46BE2C
Similar products	18-272-196811
Available
Genway ID:	GWB-46BE2C
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) (N terminal).
Antigen Species:	Human
Positive Control:	Jurkat cells
Target:	Caspase 6
Localization:	Cytoplasmic
Concentration:	0. 5 mg/ml Storage
Preservative:	Sodium Azide. Constituents: BSA 10mM PBS. pH 7. 4
Application Note:	WB: Use Ab 2. 5-5µ g/ml for 2hrs at RT. Predicted
Molecular Weight:	34 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic Caspases play a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells and are activated in response to distinct apoptosis inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase 6 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.
Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro as well as lamins. Overexpression promotes programmed cell death.
Catalytic Activity:	Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-\|-.
Enzyme Regulation:	Activation is suppressed by phosphorylation at Ser-257.
Subunit:	Heterotetramer that consists of two anti-parallel arranged heterodimers each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.
Subcellular Location:	Cytoplasm.
Ptm:	Cleavages by caspase-3 caspase-8 or -10 generate the two active subunits.
Similarity:	Belongs to the peptidase C14A family [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.25 mg

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Delivery expected until 9/11/2025

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