IgA

Item no.	18-272-197092
Manufacturer	GENWAY
Amount	1 ml
Category	Oncology Antibodies Immunohistochemistry Secondary Antibodies By Organ Lymphatic System Cancer
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1F7D3E
Similar products	18-272-197092
Available
Genway ID:	GWB-1F7D3E
Isotype:	unknown
Immunogen:	IgA isolated from a pool of normal human sera.
Antigen Species:	Human
Specificity:	This antibody reacts with alpha-chains of human IgA. This antibody has been absorbed to very high level of specificity.
Positive Control:	Tonsil
Target:	IgA Storage
Preservative:	Sodium Azide
Application Note:	This antibody may be diluted to a titer of 1:25-1:100 in an ABC method. We suggest an incubation period of 30 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer pH 6. 0 prior to immunostaining. Cellular
Localization:	Cytoplasmic
Function:	Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
Subunit:	Monomeric or polymeric.
Ptm:	3-Hydroxykynurenine an oxidized tryptophan metabolite that is common in biological fluids reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
Disease:	A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1; 14)(q21; q32) that forms a FCRL4-IGHA1 fusion protein.
Similarity:	Contains 3 Ig-like (immunoglobulin-like) domains.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 ml

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Delivery expected until 10/30/2025

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