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Pumilio 1

Pumilio 1

Item no.	18-272-197245
Manufacturer	GENWAY
Amount	0.05 ml
Category	Oncology Antibodies Immunoprecipitation Western Blot Primary Antibodies By Organ Brain Cancer
Type	Antibody
Applications	WB, IP
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-55E7BF
Similar products	18-272-197245
Available
Genway ID:	GWB-55E7BF
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) - which represented a portion of human Pumilio homolog 1 encoded in part by exons 5 and 6.
Antigen Species:	Human
Specificity:	This antibody is specific for human Pumilio.
Positive Control:	HeLa cell extract
Target:	Pumilio 1
Concentration:	1 mg/ml Storage
Buffer:	Tris-citrate/phosphate pH 7-8 containing 0. 09% sodium azide
Application Note:	For IP: Use at a concentration of 1-5 µ g/mg lysate. For WB: Use at a dilution of 1:10 000-1:50 000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Function:	Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3\' -UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
Subunit:	Binds in a sequence-specific manner to the 3\' -UTR of some mRNAs.
Subcellular Location:	Cytoplasm (Probable).
Tissue Specificity:	Expressed in brain heart kidney muscle intestine and stomach. Not expressed in cerebellum corpus callosum caudate nucleus hippocampus medulla oblongata and putamen. Expressed in all fetal tissues tested.
Induction:	Strongly down-regulated in keratinocytes upon ultraviolet B radiation.
Domain:	The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs.
Similarity:	Contains 1 PUM-HD domain.
Similarity:	Contains 8 pumilio repeats.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 ml

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