VEGF receptor 2 phospho Y1054

GWB-85F6F9

Synthetic phospho peptide containing Tyrosine 1054. The sequence is conserved in mouse and rat.

VEGFR 3 (100%) has not been tested but is expected to react.

VEGF receptor 2

0. 5 mg/ml

0. 05% Sodium Azide; Constituents: PBS 1mg/ml BSA (IgG protease free). pH 7. 3

Type I membrane protein Vascular endothelial growth factor receptor 2 (VEGFR 2 also known as KDR / FLK 1) is a 200 kDa member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development wound healing cell proliferation migration and differentiation. Like other growth factor receptors upon ligand binding VEGFR 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2- and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGFR 2 and its intrinsic tyrosine kinase activity.

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Membrane; Single-pass type I membrane protein.

Contains 7 Ig-like C2-type (immunoglobulin-like) domains.