VWF

Item no.	18-272-197563
Manufacturer	GENWAY
Amount	0.1 ml
Category	Antibodies Immunohistochemistry Primary Antibodies
Type	Antibody
Applications	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2913F2
Similar products	18-272-197563
Available
Genway ID:	GWB-2913F2
Isotype:	IgG
Immunogen:	Full length native protein (purified from plasma) (Human).
Antigen Species:	Human
Specificity:	The product specifically reacts with the cytoplasm of human endothelial cells from normal and neoplastic blood and from lymphatic vessels. It also reacts with human endocardium platelets and megakaryocytes.
Target:	VWF
Concentration:	7. 8 mg/ml
Purification Note:	From polyclonal serum Storage
Buffer:	0. 01 M phosphate-buffered saline pH 7. 4 containing 15 mM sodium azide
Application Note:	For IHC-Fr: Use at an assay dependent dilution. For IHC-P: Use at a dilutioin of 1:800. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Human von Willebrand factor (factor VIII R:Ag) is a 270kD multimeric plasma glycoprotein. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. The von Willebrand factor has functional binding domains to platelet glycoprotein Ib glycoprotein IIb/IIIa collagen and heparin. The factor is synthesized by endothelial cells and is also present in platelets and megakaryocytes.
Function:	Important in the maintenance of hemostasis it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII delivering it to the site of injury stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Subunit:	Multimeric. Interacts with F8.
Subcellular Location:	Secreted. Secreted extracellular space extracellular matrix. Note=Localized to storage granules.
Tissue Specificity:	Plasma.
Domain:	The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
Ptm:	All cysteine residues are involved in intrachain or interchain disulfide bonds.
Disease:	Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400 277480]. VWD is characterized by frequent bleeding (gingival minor skin quantitative lacerations menorrhagia etc. ). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.
Similarity:	Contains 1 CTCK (C-terminal cystine knot-like) domain.
Similarity:	Contains 4 TIL (trypsin inhibitory-like) domains.
Similarity:	Contains 3 VWFA domains.
Similarity:	Contains 3 VWFC domains.
Similarity:	Contains 4 VWFD domains.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 ml

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Delivery expected until 8/28/2025

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