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Leptin receptor

Leptin receptor

Item no.	18-272-197586
Manufacturer	GENWAY
Amount	0.05 mg
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Obesity Western Blot Endocrine Regulation of Lipid Metabolism Primary Antibodies
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D62D19
Similar products	18-272-197586
Available
Genway ID:	GWB-D62D19
Isotype:	IgG
Immunogen:	Recombinant fragment - amino acids 25-208 of Mouse Leptin Receptor
Antigen Species:	Mouse
Target:	Leptin receptor
Concentration:	1 mg/ml
Purification Note:	From polyclonal serum Storage
Buffer:	Phosphate buffered saline pH 7. 2 containing 0. 1% sodium azide
Application Note:	For WB: Use at a dilution of 1:1 800 - 1:2 200. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. OB (or leptin) is a 16-kD protein produced primarily in white adipose tissue but also in brown fat and the placenta. It was first identified by positional cloning (ref 1). It is involved in regulating the food intake energy expenditure whole-body energy balance in rodents and humans (ref 2-5). In addition to its metabolic control role OB also plays important roles in reproduction immunological response endocrine-endocrine signaling (ref 6).
Function:	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subunit:	Interacts with SIGLEC6.
Subcellular Location:	Secreted.
Disease:	Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
Similarity:	Belongs to the leptin family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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