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Thymidylate Synthase*B1G1

Thymidylate Synthase*B1G1

Item no.	18-272-197651
Manufacturer	GENWAY
Amount	1 mg
Type	Antibody
Applications	WB, IF, IP, IHC, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-1166CF
Similar products	18-272-197651
Available
Genway ID:	GWB-1166CF
Isotype:	IgG
Immunogen:	Recombinant human Thymidylate Synthase (36 kDa) produced in E. coli .
Antigen Species:	Human
Specificity:	Detects Thymidylate Synthase by immunochemistry in proliferating cell cultures and tissues but does not stain non-proliferating cells. Normal colon mucosa shows weak staining. However some colorectal cancer specimens show very strong staining.
Target:	Thymidylate Synthase
Localization:	Nuclear
Concentration:	10 mg/ml
Purification Note:	From polyclonal serum. Storage
Buffer:	0. 02 M Potassium phosphate 0. 15 M sodium chloride pH 7. 2 containing 0. 01% sodium azide
Application Note:	ELISA: 1:10 000 using Immunoprecipitation: 1:500 (pre-clearing with a non-specific sheep IgG is helpful to reduce background)Immunofluorescence microscopy Immunohistochemistry (paraffin sections). Immunoblotting: 1:1 000 - 1:5 000 using . Reactivity in other immunoassays is unknown. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear Because inhibition of Thymidylate Synthase (TS) prevents DNA synthesis and cell proliferation the enzyme is an important target for cancer chemotherapeutic drugs specifically the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors.
Catalytic Activity:	5 10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway:	Pyrimidine metabolism; dTTP biosynthesis.
Subunit:	Homodimer.
Similarity:	Belongs to the thymidylate synthase family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 9/25/2025

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