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Fibrinogen (HRP)*B1G1

Fibrinogen (HRP)*B1G1

Item no.	18-272-197654
Manufacturer	GENWAY
Amount	1 mg
Category	Antibodies Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot ELISA Primary Antibodies
Type	Antibody
Applications	WB, IHC, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-9E50D6
Similar products	18-272-197654
Available
Genway ID:	GWB-9E50D6
Isotype:	IgG
Immunogen:	Fibrinogen [Human Plasma]
Antigen Species:	Human
Specificity:	This antibody recognises human fibrinogen a 340 kD glycoprotein which plays an important role in the coagulation process.
Target:	Fibrinogen
Localization:	Secreted
Conjugation:	HRPConjugation
Note:	Conjugated to horseradish peroxidase (HRP)
Concentration:	10 mg/ml
Purification Note:	From polyclonal serum Storage
Buffer:	0. 02 M Potassium Phosphate 0. 15 M Sodium Chloride pH 7. 2 10 mg/ml Bovine Serum Albumin (BSA) IgG and Protease free containing 0. 01% (w/v) Gentamicin Sulfate
Application Note:	Dot: Use at an assay dependant dilution. ELISA: Use at a dilution of 1:20 000 - 1:100 000. IHC-Fr: Use at an assay dependant dilution. IM: Use at an assay dependant dilution. WB: Use at an assay dependant dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Secreted Fibrinogen exists as a soluble dimer (340 kDa) in plasma. Each monomer is composed of an alpha chain (63. 5 kDa) a beta chain (56 kDa) and a gamma chain (47 kDa). Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body.
Function:	Fibrinogen has a double
Function:	yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
Subunit:	Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
Subcellular Location:	Secreted.
Domain:	A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back contributing a fourth strand to the coiled coil structure.
Ptm:	The alpha chain is not glycosylated.
Ptm:	Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue forming fibronectin-fibrinogen heteropolymers.
Ptm:	About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Ptm:	Conversion of fibrinogen to fibrin is triggered by thrombin which cleaves fibrinopeptides A and B from alpha and beta chains and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Disease:	Defects in FGA are a cause of congenital afibrinogenemia [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations.
Disease:	Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Disease:	Defects in FGA are a cause of amyloidois type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1 fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome arterial hypertension hepatosplenomegaly cholestasis petechial skin rash.
Similarity:	Contains 1 fibrinogen C-terminal domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 10/30/2025

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