XAB2

GWB-9EE477

Peptide corresponding to the carboxy-terminus of human XAB2.

XAB2

0. 5 mg/ml

Phosphate-buffered saline pH 7. 2 containing no preservatives

Nuclear XAB2 (XPA-binding protein 2) was first identified through its interaction with XPA. Immunoprecipitation experiments have also demonstrated that a fraction of XAB2 interacts with the transcription-coupled repair-specific proteins CSA and CSB as well as with RNA polymerase II. Microinjection experiments with XAB2 antibodies resulted in the inhibition of both transcription-coupled repair and transcription.

Associates with RNA polymerase II the TCR-specific proteins CKN1/CSA and ERCC6/CSB and XPA. Identified in the spliceosome C complex at least composed of AQR ASCC3L1 C19orf29 CDC40 CDC5L CRNKL1 DDX23 DDX41 DDX48 DDX5 DGCR14 DHX35 DHX38 DHX8 EFTUD2 FRG1 GPATC1 HNRPA1 HNRPA2B1 HNRPA3 HNRPC HNRPF HNRPH1 HNRPK HNRPM HNRPR HNRPU KIAA1160 KIAA1604 LSM2 LSM3 MAGOH MORG1 PABPC1 PLRG1 PNN PPIE PPIL1 PPIL3 PPWD1 PRPF19 PRPF4B PRPF6 PRPF8 RALY RBM22 RBM8A RBMX SART1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SFRS1 SKIV2L2 SNRPA1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNW1 SRRM1 SRRM2 SYF2 SYNCRIP TFIP11 THOC4 U2AF1 WDR57 XAB2 and ZCCHC8.

Belongs to the crooked-neck family.