Cysteinyl leukotriene receptor 1

GWB-5F92BD

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle edema eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 & gt; & gt; LTE4 = LTC4 & gt; & gt; LTB4.

Widely expressed with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues such as lung (mostly in smooth muscle bundles and alveolar macrophages) placenta small intestine pancreas colon and heart.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The cysteinyl leukotrienes LTC4 LTD4 and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle oedema eosinophil migration and damage to the mucus layer in the lung. [1] Zhu J. Qiu Y. S. Figueroa D. J. Bandi V. Galczenski H. Hamada K. Guntupalli K. K. Evans J. F. and Jeffery P. K. Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa[2] Woszczek G. Pawliczak R. Qi H. Y. Nagineni S. Alsaaty S. Logun C. and Shelhamer J. H. Functional characterization of human cysteinyl leukotriene 1 receptor gene structure[3] Naik S. Billington C. K. Pascual R. M. Deshpande D. A. Stefano F. P. Kohout T. A. Eckman D. M. Benovic J. L. and Penn R. B. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling[4] Nielsen C. K. Campbell J. I. Ohd J. F. Morgelin M. Riesbeck K. Landberg G. and Sjolander A. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells[5] Corrigan C. Mallett K. Ying S. Roberts D. Parikh A. Scadding G. and Lee T. Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis[6] Lynch K. R. O\' Neill G. P. Liu Q. Im D. -S. Sawyer N. Metters K. M. Coulombe N. Abramovitz M. Figueroa D. J. Zeng Z. et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. [7] Sarau H. M. Ames R. S. Chambers J. Ellis C. Elshourbagy N. Foley J. J. Schmidt D. B. Muccitelli R. M. Jenkins O. Murdock P. R. et al. Identification molecular cloning expression and characterization of a cysteinyl leukotriene receptor. [8] Warren C. N. Aronstam R. S. Sharma S. V. Isolation of complete coding sequence for cysteinyl leukotriene receptor 1 (CYSLTR1). [9] Ross M. T. Grafham D. V. Coffey A. J. Scherer S. McLay K. Muzny D. Platzer M. Howell G. R. Burrows C. Bird C. P. et al. The DNA sequence of the human X chromosome.