Muscarinic acetylcholine receptor M5

GWB-AE2F25

The muscarinic acetylcholine receptor mediates various cellular responses including inhibition of adenylate cyclase breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition phosphoinositide degeneration and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however stimulation of this receptor is known to increase cyclic AMP levels. [1] De Luca V. Wang H. Squassina A. Wong G. W. Yeomans J. and Kennedy J. L. Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia[2] Fujii T. Watanabe Y. Inoue T. and Kawashima K. et al. Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses[3] Buchli R. Ndoye A. Arredondo J. Webber R. J. and Grando S. A. et al. Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes[4] Wang H. Han H. Zhang L. Shi H. Schram G. Nattel S. and Wang Z. et al. Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart[5] Sato K. Z. Fujii T. Watanabe Y. Yamada S. Ando T. Kazuko F. and Kawashima K. Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines[6] Bonner T. I. Young A. C. Brann M. R. Buckley N. J. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. [7] Rae J. L. Shepard A. R. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases. [8] Wang H. Yeomans J. Human muscarinic acetylcholine receptor 5 is localized on 15q13. 1 and its expression in SH-SY5Y cells. [9] Puhl H. L. III Ikeda S. R. Aronstam R. S. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [10] Arredondo J. Grando S. A. Cloning cholinergic receptors in human keratinocytes.