C-X-C chemokine receptor type 5

C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (5 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein was identified as a gene specifically expressed in Burkitt\' s lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC a B-lymphocyte chemoattractant was identified to be a specific ligand for this receptor. Studies of this gene and its mouse conterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist. [1] Widney D. P. Breen E. C. Boscardin W. J. Kitchen S. G. Alcantar J. M. Smith J. B. Zack J. A. Detels R. and et al. Serum levels of the homeostatic B cell chemokine CXCL13 are elevated during HIV infection[2] Howard O. M. Dong H. F. Su S. B. Caspi R. R. Chen X. Plotz P. and Oppenheim J. J. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate[3] Steinmetz O. M. Panzer U. Kneissler U. Harendza S. Lipp M. Helmchen U. and Stahl R. A. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection[4] Qiuping Z. Jie X. Youxin J. Qun W. Wei J. Chun L. Jin W. Yan L. Chunsong H. Mingzhen Y. Qingping G. Qun L. Kejian Z. et al. Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia[5] Hu C. Xiong J. Zhang L. Huang B. Zhang Q. Li Q. Yang M. Wu Y. Wu Q. Shen Q. Gao Q. Zhang K. Sun Z. Liu J. Jin Y. and et al. PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia[6] Dobner T. Wolf I. Emrich T. Lipp M. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt\' s lymphoma. [7] Barella L. Loetscher M. Tobler A. Baggiolini M. Moser B. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. [8] Legler D. F. Loetscher M. Stuber Roos R. Clark-Lewis I. Baggiolini M. Moser B. B cell-attracting chemokine 1 a human CXC chemokine expressed in lymphoid tissues selectively attracts B lymphocytes via BLR1/CXCR5.