C-C chemokine receptor type 3

C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (8 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines including eotaxin (CCL11) eotaxin-3 (CCL26) MCP-3 (CCL7) MCP-4 (CCL13) and RANTES (CCL5). It is highly expressed in eosinophils and basophils and is also detected in TH1 and TH2 cells as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This protein and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. [1] Muciaccia B. Padula F. Vicini E. Gandini L. Lenzi A. and Stefanini M. Beta-chemokine receptors 5 and 3 are expressed on the head region of human spermatozoon[2] Joubert P. Lajoie-Kadoch S. Labonte I. Gounni A. S. Maghni K. Wellemans V. Chakir J. Laviolette M. Hamid Q. and Lamkhioued B. CCR3 expression and function in asthmatic airway smooth muscle cells[3] Zimmermann N. Colyer J. L. Koch L. E. and Rothenberg M. E. et al. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1[4] Venet F. Lepape A. Debard A. L. Bienvenu J. Bohe J. and Monneret G. The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock[5] Ho P. T. Teal B. E. and Ross T. M. et al. Multiple residues in the extracellular domains of CCR3 are critical for coreceptor activity[6] Combadiere C. Ahuja S. K. Murphy P. M. Cloning and functional expression of a human eosinophil CC chemokine receptor. [7] Combadiere C. Ahuja S. K. Murphy P. M. J. Biol. Chem. 270:30235-30235(1995). [8] Daugherty B. L. Siciliano S. J. Demartino J. A. Malkowitz L. Sirotina A. Springer M. S. Cloning expression and characterization of the human eosinophil eotaxin receptor. [9] Ponath P. D. Qin S. Post T. W. Wang J. Wu L. Gerard N. P. Newman W. Gerard C. Mackay C. R. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. [10] Xiao L. Weiss S. Qari S. Rudolph D. Hodge T. Lal R. Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion.